Ropeway roller batteries dynamics. Modeling, identification, and full-scale validation

A parametric mechanical model based on a Lagrangian formulation is here proposed to predict the dynamic response of roller batteries during the vehicles transit across the so-called compression towers in ropeways transportation systems. The model describes the dynamic interaction between the ropeway substructures starting from the modes and frequencies of the system to the forced dynamic response caused by the vehicles transit. The analytical model is corroborated and validated via an extensive experimental campaign devoted to the dynamic characterization of the roller battery system. The data acquired on site via a custom-design sensor network allowed to identify the frequencies and damping ratios by employing the Frequency Domain Decomposition (FDD) method. The high fidelity modeling and the system identification procedure are discussed

An Overview of Vehicular Communications

The transport sector is commonly subordinate to several issues, such as traffic congestion and accidents. Despite this, in recent years, it is also evolving with regard to cooperation between vehicles. The fundamental objective of this trend is to increase road safety, attempting to anticipate the circumstances of potential danger. Vehicle-to-Vehicle (V2V), Vehicle-to-Infrastructure (V2I) and Vehicle-to-Everything (V2X) technologies strive to give communication models that can be employed by vehicles in different application contexts. The resulting infrastructure is an ad-hoc mesh network whose nodes are not only vehicles but also all mobile devices equipped with wireless modules. The interaction between the multiple connected entities consists of information exchange through the adoption of suitable communication protocols. The main aim of the review carried out in this paper is to examine and assess the most relevant systems, applications, and communication protocols that will distinguish the future road infrastructures used by vehicles. The results of the investigation reveal the real benefits that technological cooperation can involve in road safety. Document type: Articl

"Modern" suburbs in lockdown: the INA CASA neighbourhood by Filippo Rovigo in Messina

[EN] The recent CoViD-19 emergency, a dramatic issue for our health, and the vexata quaestio of the existing buildings recovery, especially of the neighborhood, are the ends of an Ariadne's thread that must help us find an exit from the two huge problems. These issues, coupled by the isolation constrain, can be converted in a great opportunity by using targeted choices, supported by sustainability criteria that are now unavoidable.In the present paper, a specific suburban area- former Fondo Basile by architect Filippo Rovigo, on the northern edge of Messina was selected. For this area - following the original indications formulated by the emerging "neorealist" culture for garden cities – we intend: to redefine barrier-free paths; to add green and blue infrastructures; to evaluate incidences on energy performance; to redesign interior spaces to accept the need for sterilization and “flexible” furnishings; to experiment with functionalized surfaces (self-cleaning, antibacterial, heat-insulating); to introduce ad hoc home automation.Therefore, it is necessary to start from a very serious accident on which we stumbled exploiting this experience in order to look at the virus as an opportunity for a general rebirth of the neighbourhood. This latter can be based on new or experimental concepts in order to allow a sustainable restoration of the Modern Architecture, addressed to the second post-war period heritage, not guaranteed by the constrained regime provided for by the Cultural Heritage Code. This possibility is back in the fore thanks to a more recent strategic direction for the protection of "new landscapes" promoted by the Regional Department for Sicilian culture and identity.Arena, M.; Calabrese, L.; Di Bella, G.; Fiandaca, O.; Minutoli, F.; Lione, R.; Todesco, F. (2020). "Modern" suburbs in lockdown: the INA CASA neighbourhood by Filippo Rovigo in Messina. VITRUVIO - International Journal of Architectural Technology and Sustainability. 5(2):17-36. https://doi.org/10.4995/vitruvio-ijats.2020.14465OJS17365

CFD Analysis and optimization of the DEMO WCLL central outboard segment bottom-Cap elementary cell

In the design of magnetic confinement nuclear fusion power plants, the Breeding Blanket (BB) plays a crucial role, since it must fulfil key functions such as tritium breeding, radiation-shielding and removing of the heat power generated by the plasma. The latter task is achieved by the First Wall (FW) and Breeding Zone (BZ) cooling systems, that in the Water-Cooled Lithium-Lead (WCLL) BB employs pressurized water. Different arrangements of BZ coolant conduits have been investigated in the recent past to identify an efficient layout, which could meet the structural materials operational temperature constraint and that could provide the optimal coolant outlet temperature. However, most of the Computational Fluid-Dynamic (CFD) analysis carried out until now have been focused on the equatorial WCLL elementary cell of the Central Outboard Segment (COB). The aim of this work is to broaden the analysis to other relevant locations in the blanket. An assessment of the design of the cooling system of the COB bottom-cap elementary BZ cell has been identified as the top design priority due to its different geometry and thermal loads. The cooling efficiency of the BZ and FW systems is investigated to assess if the coolant appropriate design conditions are matched and the temperature distribution in the cell is analyzed to identify the onset of hot spots. Different layouts of the FW systems are proposed and compared in terms of thermal-hydraulics reliability

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturbance of PI3K/AKT/mTOR axis in DS brain, prior and after the development of Alzheimer Disease (AD). The aberrant modulation of the mTOR signalling in DS and AD age-related cognitive decline affects crucial neuronal pathways, including insulin signaling and autophagy, involved in pathology onset and progression. Within this context, the therapeutic use of mTOR-inhibitors may prevent/attenuate the neurodegenerative phenomena. By our work we aimed to rescue mTOR signalling in DS mice by a novel rapamycin intranasal administration protocol (InRapa) that maximizes brain delivery and reduce systemic side effects. Methods: Ts65Dn mice were administered with InRapa for 12 weeks, starting at 6 months of age demonstrating, at the end of the treatment by radial arms maze and novel object recognition testing, rescued cognition. Results: The analysis of mTOR signalling, after InRapa, demonstrated in Ts65Dn mice hippocampus the inhibition of mTOR (reduced to physiological levels), which led, through the rescue of autophagy and insulin signalling, to reduced APP levels, APP processing and APP metabolites production, as well as, to reduced tau hyperphosphorylation. In addition, a reduction of oxidative stress markers was also observed. Discussion: These findings demonstrate that chronic InRapa administration is able to exert a neuroprotective effect on Ts65Dn hippocampus by reducing AD pathological hallmarks and by restoring protein homeostasis, thus ultimately resulting in improved cognition. Results are discussed in term of a potential novel targeted therapeutic approach to reduce cognitive decline and AD-like neuropathology in DS individuals

An Overview on the Current Status and Future Perspectives of Smart Cars

In recent years, the smart car sector has been increasing enormously in the Internet of Things (IoT) market. Furthermore, the number of smart cars seems set to increase over the next few years. This goal will be achieved because the application of recent IoT technologies to the automotive sector opens up innovative opportunities for the mobility of the future, in which connected cars will be more and more prominent in smart cities. This paper aims to provide an overview of the current status and future perspectives of smart cars, taking into account technological, transport, and social features. An analysis concerning the approaches to making smart a generic car, the possible evolutions that could occur in the coming decades, the characteristics of 5G, ADAS (advanced driver assistance systems), and the power sources is carried out in this paper. Document type: Articl

The role of dalbavancin in the multi-disciplinary management of wound infections in orthopaedic surgery.

Antimicrobial resistance is continuously increasing among bacterial clinical isolates (especially methicillin resistance in Staphylococcus aureus, MRSA), negatively impacting on outcomes of patients with Surgical Site Infections (SSIs). A multi-disciplinary team work is essential for SSIs prevention and for the choice of antibiotic therapy of orthopaedic SSIs. In particular, an Antibiotic Stewardship (AS) approach is recommended for preserving the activity of old and new antimicrobials. Dalbavancin is a novel antimicrobial agent, belonging to the lipoglycopeptides family, recently approved by FDA for the treatment of ABSSSIs (Acute Bacterial Skin and Skin Structure Infections) and can be considered as a candidate for the treatment of orthopaedic superficial SSIs. An antimicrobial activity directed against MRSA and other multi-resistant Gram-positive pathogens, a bactericidal effect and an extremely extended half-life are among key features of this drug. Dalbavancin gives to clinicians the option to provid..

Hierarchical TiN-Supported TsFDH Nanobiocatalyst for CO2 Reduction to Formate

AbstractThe electrochemical reduction of CO2 to value‐added products like formate represents a promising technology for the valorization of carbon dioxide. We propose a proof‐of‐concept bioelectrochemical system (BES) for the reduction of CO2 to formate. For the first time, our device employs a nanostructured titanium nitride (TiN) support for the immobilization of a formate dehydrogenase (FDH) enzyme. The hierarchical TiN nanostructured support exhibits high surface area and wide pore size distribution, achieving high catalytic loading, and is characterized by higher conductivity than other oxide‐based supports employed for FDHs immobilization. We select the oxygen‐tolerant FDH from Thiobacillus sp. KNK65MA (TsFDH) as enzymatic catalyst, which selectively reduces CO2 to formate. We identify an optimal TiN morphology for the enzyme immobilisation through enzymatic assay, reaching a catalyst loading of 59 μg cm−2 of specifically‐adsorbed TsFDH and achieving a complete saturation of the anchoring sites available on the surface. We evaluate the electrochemical CO2 reduction performance of the TiN/TsFDH system, achieving a remarkable HCOO− Faradaic efficiency up to 76 %, a maximum formate yield of 44.1 μmol mg−1FDH h−1 and high stability. Our results show the technological feasibility of BES devices employing novel, nanostructured TiN‐based supports, representing an important step in the optimization of these devices